2016 Fiscal Year Final Research Report
To prevent osteoporosis using food derived phytoestrogen
| Project/Area Number |
26460794
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ゲニステイン / メナキノン-4（MK-4） / BGLAP / CHAD / ALP3 / DPP4 / 骨芽細胞様 / MC3T3-E1細胞 |
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| Outline of Final Research Achievements |
Bone is a basic component of the musculoskeletal system and is constantly remodeled due to the function of osteoblasts and osteoclasts. The bone remodeling decreased especially in women following menopause, accelerated bone loss and leas to osteoporosis. Osteoporosis is a serious social and health problem in a progressively aging society. Utilization of food-based nutrients like genistein, contained in soybeans, and menaqoinone-4, in dairy foods, are considered to be the most economical and easy way to prevent bone loss. In the present study, effect of genistein and menaquinone-4 on osteoblastic MC3T3-El cells were examined. We could isolate 21 mRNAs of which expression were increased more than three as much an control when genistein was supplied. Thereafter, co-effects of genistein and menaqoinone-4 were examined. We confirmed their simultaneous effectiveness on maintenance of using Chad and ALP.
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| Free Research Field |
衛生学
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