2017 Fiscal Year Final Research Report
Effect of neonicotinoid in the immature murine testes.
| Project/Area Number |
26460809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
坂部 貢 東海大学, 医学部, 教授 (70162302)
遠藤 整 東海大学, 医学部, 講師 (10550551)
内藤 宗和 愛知医科大学, 医学部, 教授 (10384984)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | ネオニコチノイド / 精巣 / マウス / 未成熟 |
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| Outline of Final Research Achievements |
Neonicotinoids belong to a new and widely used pesticides, and are thought to be safe to humans. With mimic chemical structures to nicotine, neonicotinoids also have agonist activity at nicotine acetylcholine receptor (nAchR). However, it has been recently reported that neonicotinoids have been are implicated in a number of human health disorders. Actually, nAChR have is expressed in not only the nervous system but also the reproductive system. In the testis, spermatid / sperm appear by meiosis when reach puberty. Therefore, the environment inside the testis changes dramatically after the puberty. Until now, when administering neonicotinoid pesticides to adult mice, decrease of testosterone has been reported. However, there has been no report about the effect of neonicotinoid pesticide in juvenile stage. In present study, we immunotoxically analyzed the testicular environment of oral administration neonicotinoid pesticide in the immature mice.
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| Free Research Field |
解剖学、生殖医学
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