2016 Fiscal Year Final Research Report
Forensic pathogenesis based on gene expression expressed during death interval.
| Project/Area Number |
26460876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
nishi katsuji 滋賀医科大学, 医学部, 客員教授 (60073681)
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| Research Collaborator |
SAKAGUCHI Ikuo
OKUNAGA Hayato
NAKAGAWA Tokiko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 法医病理 / 脳・心関連 / 法医病理学 |
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| Outline of Final Research Achievements |
We examined distribution of hypoxic related antigens, which are expressed during agonal duration in the brain and heart, for application to forensic pathogenesis and diagnosis. We could observed that (1) glycoconjugate deposits in the molecular layer of hippocampus from cognitive patients, (2) reperfusion in brain or heart causes intensive injury, (3) expression of HIF1α is increasing with length of agonal duration, (4) RBM3 which is protector item to hypothermia has an important role as vaso-expansion, and (5) RBM3 is independently expressed in the nuclei of Sabstantia nigra of individuals died from neck-compression deaths.
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| Free Research Field |
法医学
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