2016 Fiscal Year Final Research Report
Correspondence analysis of gene expressions in hypothermic adrenal gland, heart, kidney, liver, and lung using DNA microarray
| Project/Area Number |
26460884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 低体温症 / 肝臓 / 肺 / DNA microarray / quantitative PCR / 対応分析 |
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| Outline of Final Research Achievements |
We analyzed the hepatic and pulmonary transcriptome of mice killed by hypothermia using DNA microarray technology. The present study demonstrated acute hepatic and pulmonary responses in hypothermia, and we suggest that understanding hepatic and pulmonary mRNA expression would be useful for hypothermia diagnosis. Furthermore, the present microarray data may facilitate development of immunohistochemical analyses that could be used for human autopsies. Corresponding analyses were also performed concerning to gene expressions in hypothermic adrenal gland, heart, kidney, liver, and lung. These analyses would reveal relationships among these organs in hypothermia.
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| Free Research Field |
法医学
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