The elucidation of the mechanism for regulating gene expression in metabolic syndrome in the eldrly.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460905
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Osaka University
• Principal Investigator: OGURO RYOSUKE 大阪大学, 医学部附属病院, 特任助教(非常勤) (70630705)
• Co-Investigator(Renkei-kenkyūsha): GONDO Yasuyuki 大阪大学, 人間科学研究科, 准教授 (40250196) ; IKEBE Kazunori 大阪大学, 歯学系研究科, 准教授 (70273696)
• Research Collaborator: RYUNO Hirochika
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 高齢者 / メタボリック症候群 / 遺伝子多型 / ADAR遺伝子 / 脂質異常症

Outline of Final Research Achievements

A single nucleotide polymorphism of the adenosine deaminase, RNA-specific (ADAR) gene “rs2805533 (A/G) ” was significantly associated with serum triglyceride(TG) level, and a criteria for metabolic syndrome (TG≧150mg/dl and/or HDL < 40mg/dl ) in 70 ± 1 elderly. Three years later, rs2805533 was also significantly associated with serum TG level, serum high density lipoprotein (HDL) cholesterol level, and a criteria for metabolic syndrome (TG≧150mg/dl and/or HDL < 40mg/dl ) in 73 ± 1 elderly. In this study population, the subject with G allele had higher risk for dyslipidemia. In this cohort analysis, rs2805533 was significantly associated with the delta of HDL cholesterol level (ΔHDL) between 70(±1) and 73(±1) years, and the subject with GG genotypes had lower HDL cholesterol level than AA and AG genotypes.

Free Research Field

医歯薬学、老年医学