Clinical Analysis of Neurodegenerative Dementia Using Cerebrospinal Fluid Biomarkers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Juntendo University
• Principal Investigator: Yumiko Motoi 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (60338407)
• Co-Investigator(Renkei-kenkyūsha): HATTORI Nobutaka 順天堂大学, 脳神経内科, 教授 (80218510) ; NISHIOKA Kenya 順天堂大学, 脳神経内科, 准教授 (40348933) ; YORITAKA Asako 順天堂大学, 脳神経内科, 准教授 (90245720) ; SHIMURA Hideki 順天堂大学, 脳神経内科, 准教授 (50286746) ; MACHIDA Yu 順天堂大学, 脳神経内科, 准教授 (90317470) ; Nakamura Shinishiro 順天堂大学, 脳神経内科, 准教授 (80407296)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アルツハイマー病 / 皮質基底核症候群 / 進行性失語症 / ドパーミントランスポーターシンチグラフィ / 脳血流シンチ / 髄液マーカー

Outline of Final Research Achievements

Alzheimer disease (AD) pathology can underlie corticobasal syndrome (CBS) and primary progressive aphasia (PPA). Our study showed that CBS patients with AD-like CSF findings showed higher frequency of forgetfulness at onset, and lower MMSE score than those with non-AD pattern. They also decreased regional cerebral blood flow (rCBF) of the temporoparietal cortex in SPECT. Two semantic dementia (SD) patients with AD-like CSF showed decreased rCBF of the parietal, occipital and frontal cortex while marked decreased rCBF only in the left temporal cortex was noted in 4 SD patients with non-AD pattern. 2 non-fluent aphasia patients with non-AD like CSF exhibited low binding of dopamine transporter in the basal ganglia. We conclude that clinical symptoms, rCBF SPECT and Dopamine transporter scan are very helpful to make a diagnosis of CBS-AD and PPA-AD.

Free Research Field

神経科学