2016 Fiscal Year Final Research Report
Analysis of cancer stem cell niche by using esophageal orgnotypic 3D culture system
| Project/Area Number |
26460933
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 癌幹細胞 / 癌幹細胞ニッチ / EGFR阻害剤 / 食道扁平上皮癌 |
|---|
| Outline of Final Research Achievements |
We analyzed cacner stem cell niche of esophageal squamous cell carcinoma (ESCC) by using organotypic 3D culture system. Invasive fronts formed cancer stem cell niche in ESCC and epithelial-mesenchymal transition (EMT) had a pivotal role for maintenance of cancer stem cells. EGF released from fibroblasts induced EMT and cancer stem cells were increased in invasive fronts of ESCC. EGFR inhibitors suppressed EMT and formation of cancer stem cell niche and cancer stem cells were decreased in organotypic 3D culture.
|
| Free Research Field |
腫瘍学
|
