[13C]-naproxen breath test can predict the gastric mucosal injury induced by naproxen

2016 Fiscal Year Final Research Report

• Project/Area Number: 26460935
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: FURUTA TAKAHISA 浜松医科大学, 医学部附属病院, 准教授 (10303546)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 呼気試験 / ナプロキセン

Outline of Final Research Achievements

W examined whether a [13C]-naproxen breath test ([13C]-NBT) could serve as the predictor of the gastric mucosal injuries induced by naproxen. We found that [13C]-NBT reflected metabolic profiles and the effect of naproxen on prostaglandin levels and could serve as a predictive marker of naproxen-induced gastric mucosal injury. We next prospectively tested the usefulness of [13C]-NBT for the tailored prophylaxis therapy for naproxen-induced gastric mucosal injuries. We found that [13C]-NBT was useful to select the subjects who were at the high risk of gastric mucosal injury on naproxen and needed the prophylaxis treatment with a PPI.

Free Research Field

消化器内科学