2016 Fiscal Year Final Research Report
Development of a novel photodynamic therapy with sugar-conjugated chlorin targeting tumor-associated macrophages in cancer stroma.
Project/Area Number |
26460947
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Nagoya City University |
Principal Investigator |
KATAOKA Hiromi 名古屋市立大学, 大学院医学研究科, 准教授 (40381785)
|
Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Testuya 獨協医科大学, 医学部, 教授 (90348029)
TANAKA Mamoru 名古屋市立大学, 大学院医学研究科, 臨床研究医 (80617861)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 光線力学的療法 / 光線力学的診断法 / PDT / PDD / 光感受性物質 / LED / LASER |
Outline of Final Research Achievements |
Photodynamic therapy (PDT) using mannose-conjugated chlorin (M-chlorin) designed to target tumor-associated macrophages (TAMs) in cancer stroma (which express high level of mannose receptors) showed very strong cytotoxicity against not only TAMs but also cancer cells. We also synthesized oligosaccharide-conjugated chlorin (O-chlorin) with improved water-solubility. O-chlorin showed very excellent photodynamic diagnosis effects as well as PDT effects.
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Free Research Field |
消化器内科学
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