2016 Fiscal Year Final Research Report
Clarification the pathophysiology of functional dyspepsia
| Project/Area Number |
26460950
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Research Collaborator |
IZUMI Kentaro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 機能性ディスペプシア / 胃内圧 / 酸分泌抑制薬 / 抗うつ薬 / 抗不安薬 / 多剤併用療法 |
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| Outline of Final Research Achievements |
Functional dyspepsia (FD) is defined as the presence of dyspeptic symptoms in the absence of an organic cause that readily explains them. Although FD is a common disease, mechanisms by which generate symptoms has not been fully understood. We revealed that fasting intragastric pressure may affect the sensation of satiation by high resolution manometry study. Regarding diagnosis, we revealed that minor findings such as erythema, erosion or edema in upper GI endoscopy did not correlate with symptom, in other words, these findings were not necessary to recognize as organic cause. Regarding treatment, we evaluated the efficacy of newly developed anti-acid drug and proved its potent effect and we also showed the effectiveness of antianxiety or antidepressive agents in alleviating FD symptoms. However, efficacy of multidrug therapy was limited in our pilot study. These studies should contribute to construct the evidences to develop adequate therapeutic strategy.
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| Free Research Field |
消化器内科学 機能性消化管疾患
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