2016 Fiscal Year Final Research Report
Whole-exome sequencing identifies a novel genetic susceptibility locus in autoimmune liver diseases
| Project/Area Number |
26460996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shinshu University |
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Principal Investigator |
UMEMURA Takeji 信州大学, 学術研究院医学系, 准教授 (30419345)
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| Co-Investigator(Renkei-kenkyūsha) |
OTA Masao 信州大学, 学術研究院医学系, 准教授 (50115333)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | AIH / PBC / HLA / PTPN22 / sCD14 / IL-8 / M2BP / 細胞死 |
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| Outline of Final Research Achievements |
The key findings in this study were: (1) HLA, PTPN22, and PRKCB genes are significantly associated with susceptibility and resistance to autoimmune liver diseases (autoimmune hepatitis and primary biliary cholangitis) in Japan; (2) Serum Mac-2-binding protein, cell death, soluble CD14, and IL-8 levels were simple, and reliable noninvasive surrogate marker of liver fibrosis and prognosis in patients with primary biliary cholangitis.
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| Free Research Field |
肝臓病学
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