2016 Fiscal Year Final Research Report
Intracellular trafficking in the liver
| Project/Area Number |
26461002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
GAO Nan Rutgers University, Associate Professor
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 細胞内輸送 |
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| Outline of Final Research Achievements |
Rab11a, one of the small GTPases, is required for intracellular trafficking. We hypothesized that Rab11a involves in intracellular trafficking of lipid; absorption, metabolism and excretion. Hepatocyte specific Rab11a knockout mice were produced and survived as long as normal control mice. High fat diet was given for producing the NAFLD model mice for analysis of lipid metabolism in the liver. Results of increase of body weight and lipid accumulation in knockout mice were obtained. Hepatocyte Rab11a was related with intracellular lipid accumulation.
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| Free Research Field |
消化器内科
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