Factors for favorable acquirement of anti-HBsAb by HBV vaccination in healthy adults

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461027
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: Murata Kazumoto 国立研究開発法人国立国際医療研究センター, その他部局等, 肝炎・免疫研究センター室長 (40345971)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: HBVワクチン / 抗体獲得不良 / 細胞内シグナル / 不顕性感染

Outline of Final Research Achievements

We analyzed a frequency of anti-HBs positive healthy volunteers (HV) without anti-HBc (that means previous infection of HBV). The frequency of anti-HBs positive with or without anti-HBc was similar. We found some HV did not memorize their histories of HBV vaccination, suggesting that each hospital should precisely control it.
We analyzed miR-181a in the naive CD4-T cells to study the factors for poor responses against HBV vaccination. miR-181a expression in the naive CD4-T cells was gradually decreased by their ages as previously reported. However, we were not able to demonstrate the association between miR-181a expression and poor response against HBV vaccination.　We thought one of factors for it should be multiple backgrounds of HBV vaccinees.

Free Research Field

肝臓内科