2016 Fiscal Year Final Research Report
Identification of Warburg effect inducer in pancreatic cancer
| Project/Area Number |
26461029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | Tohoku University |
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Principal Investigator |
Hamada Shin 東北大学, 医学系研究科, 助教 (20451560)
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 膵癌 / 細胞内代謝 |
|---|
| Outline of Final Research Achievements |
This research project aimed to clarify the role of Warburg effect on malignant behavior of pancreatic cancer cells. For this purpose, we established tetracycline-inducible miR-197 expressing cell line. Induction of miR-197 suppressed oxygen consumption in this cell line. Furthermore, multiple components of oxidative phosphorylation and electron transport system were down-regulated. In addition, stimulation by pancreatic stellate cell-conditioned medium, was also found to affect cellular metabolism of pancreatic cancer.
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| Free Research Field |
医歯薬学
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