The establishment of novel endoscopic diagnostic method and biomarker for cholangiocarcinoma by fluorescence in situ hybridization

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: NAITOH Itaru 名古屋市立大学, 大学院医学研究科, 講師 (30527750)
• Co-Investigator(Kenkyū-buntansha): 中沢 貴宏 名古屋市立大学, 大学院医学研究科, 研究員 (70305522) ; 宮部 勝之 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00543985)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: FISH法 / 胆管癌 / IgG4関連硬化性胆管炎 / 胆管生検 / 染色体異常

Outline of Final Research Achievements

We evaluated the efficacy of fluorescence in situ hybridization (FISH) using transpapillary forceps biopsy specimens in the diagnosis of cholangiocarcinoma (CCA). We evaluated the copy number gains (> 2 copies) of CEP 3, 7, and 17 in patients with CCA and IgG4-related sclerosing cholangitis (IgG4-SC). The complementary use of FISH analysis using transpapillary forceps biopsy specimens improves the diagnostic yield for CCA in the differential diagnosis from IgG4-SC. Furthermore, a CEP 7 copy number gain may be a biomarker of poor prognosis in CCA patients.

Free Research Field

消化器内科　胆膵領域