Basic researches of allogeneic cell sheets and novel devices for esophageal regeneration

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Kanai Nobuo 東京女子医科大学, 医学部, 特任講師 (90318056)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 細胞治療 / 細胞シート / アンメットメディカルニーズ / 3Dプリンター / 移植デバイス / 再生医療 / 同種細胞

Outline of Final Research Achievements

In order to overcome the unmet medical needs in the field of the esophageal area, we are developing of esophageal regenerative treatment using epithelial cell sheet. In this project, we researched the feasibility of allogeneic cell sheet transplantation in a porcine model and developed the novel delivery devices for cell sheets transplantation using 3D printer. In this basic research, We succeeded in developing the animal esophageal stricture model and obtained results that allogeneic cell sheets transplantation avoiding severe esophageal stricture. In developing research, We successfully developed endoscopic delivery devices for sheet-like therapeutic substances using 3D printer.

Free Research Field

再生医療