Molecular imaging of disease activity in pulmonary arterial hypertension

2016 Fiscal Year Annual Research Report

• Project/Area Number: 26461097
• Research Institution: Kurume University
• Principal Investigator: 田原 宣広 久留米大学, 医学部, 准教授 (10320186)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 肺高血圧 / 分子イメージング

Outline of Annual Research Achievements

本研究は、肺動脈性肺高血圧症 (PAH)症例の肺血管障害や右心負荷の程度をFDG-PET/CTを用いて定量評価し、肺血管拡張療法の治療効果を肺血行動態も含めて評価する。肺血管障害や右心負荷の程度を非侵襲的に繰り返して定量評価することで、病勢を把握し、治療に反映させることを目的としている。

平成28年度は、申請計画書に従ってPAH症例に肺血管拡張薬による治療を行い、薬効評価として肺血行動態を評価する時期にFDG-PET/CTを再検する症例を増やして検討した。肺血行動態の改善に伴い、視覚的・定量的に右室のFDG集積が有意に低下しており、治療効果の指標として有用と考えられた。また、肺血管障害として肺野のFDG集積を静脈相のFDG集積で補正して検討し、肺血管抵抗が改善した例では肺野のFDG集積は変化を認めなかったが、肺血管抵抗の改善が不十分例では肺野のFDG集積が有意に増加した。

次に、右室のFDG集積に関連する因子についてステップワイズ法を用いた重回帰分析を行うと、右室駆出率、肺動脈平均圧、NTproBNPが独立して関連する因子であった。また、治療介入により変化した右室のFDG集積 (Δ)には、Δ右室駆出率のみが独立して関連していた。

Research Products

• [Journal Article] Right ventricular workload assessed by FDG-PET in a patient with residual VSD and infundibular pulmonary stenosis after repair of tetralogy of Fallot. (2017)
  • Author(s): Nakamura T, Tahara N, Tahara A, Honda A, Igata S, Bekki M, Sugiyama Y, Sun J, Kumagai E, Kurata S, Fujimoto K, Abe T, Kato S, Tanaka H, Fukumoto Y.
  • Journal Title: J Nucl Cardiol. Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s12350-017-0906-z
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects. (2017)
  • Author(s): Tahara A, Tahara N, Yamagishi SI, Honda A, Igata S, Nitta Y, Bekki M, Nakamura T, Sugiyama Y, Sun J, Takeuchi M, Shimizu M, Yamazaki H, Fukami K, Fukumoto Y.
  • Journal Title: Int J Food Sci Nutr. Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1080/09637486.2017.1318117
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension. (2017)
  • Author(s): Tanabe N, Ikeda S, Tahara N, Fukuda K, Hatano M, Ito H, Nakayama T, Anzai T, Hashimoto A, Inoue T, Kajinami K, Kihara Y, Kinoshita H, Kuwahara K, Murohara T, Okazaki O, Sakai S, Satoh T, Takeda Y, Takeishi Y, Taniguchi M, Watanabe H, Yamamoto T, Yamauchi-Takihara K, Yoshioka K, Sasayama S.
  • Journal Title: Circ J. Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1253/circj.CJ-16-1348
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myocardial metabolic improvement prior to electrocardiographic or volumetric changes of the right ventricle in pulmonary arterial hypertension. (2017)
  • Author(s): Nakamura T, Tahara N, Tahara A, Honda A, Bekki M, Sugiyama Y, Sun J, Kumagai E, Kurata S, Fujimoto K, Abe T, Igata S, Fukumoto Y.
  • Journal Title: J Nucl Cardiol. Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s12350-016-0769-8
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Acute heart failure caused by mechanical valve leaflet dislodgment at the mitral position. (2017)
  • Author(s): Nakamura T, Masumoto A, Tahara N, Kuroda Y, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: 38(10) Pages: 761
  • DOI: 10.1093/eurheartj/ehw521
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differential Expression of Cardiac Troponin T and I in a Patient with Isolated Skeletal Muscular Sarcoidosis. (2016)
  • Author(s): Mannoji H, Hayashi F, Kubota T, Ikeda Y, Ishibashi-Ueda H, Kato S, Tahara N, Fukutomi T, Yamada T, Okabe M, Yamamoto Y.
  • Journal Title: Intern Med. Volume: 55(21) Pages: 3215-3217
  • DOI: 10.2169/internalmedicine.55.6888
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vascular Inflammation Evaluated by [18F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction. (2016)
  • Author(s): Honda A, Tahara N, Nitta Y, Tahara A, Igata S, Bekki M, Nakamura T, Sugiyama Y, Kaida H, Kurata S, Fujimoto K, Abe T, Enomoto M, Adachi H, Narula J, Yamagishi S, Fukumoto Y.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36(9) Pages: 1980-1988
  • DOI: 10.1161/ATVBAHA.116.307293
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Anagliptin, A Dipeptidyl Peptidase-4 Inhibitor Ameliorates Arterial Stiffness in Association with Reduction of Remnant-Like Particle Cholesterol and Alanine Transaminase Levels in Type 2 Diabetic Patients. (2016)
  • Author(s): Tahara N, Yamagishi SI, Bekki M, Kodama N, Nakamura T, Sugiyama Y, Oshige T, Kumashiro Y, Honda A, Tahara A, Igata S, Fukumoto Y.
  • Journal Title: Curr Vasc Pharmacol. Volume: 14(6) Pages: 552-562
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] In Vivo Molecular Imaging of Ruptured Coronary Atherosclerotic Plaque Using IVUS, OCT, and FDG-PET/CT. (2016)
  • Author(s): Koiwaya H, Tahara N, Tahara A, Honda A, Igata S, Bekki M, Nakamura T, Sugiyama Y, Ohtsuka M, Kurata S, Fujimoto K, Abe T, Shibata Y, Ueno T, Fukumoto Y.
  • Journal Title: JACC Cardiovasc Interv. Volume: 9(12) Pages: e113-5
  • DOI: 10.1016/j.jcin.2016.03.013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy and Safety of a Novel Endothelin Receptor Antagonist, Macitentan, in Japanese Patients With Pulmonary Arterial Hypertension. (2016)
  • Author(s): Tahara N, Dobashi H, Fukuda K, Funauchi M, Hatano M, Ikeda S, Joho S, Kihara Y, Kimura T, Kondo T, Matsushita M, Minamino T, Nakanishi N, Ozaki Y, Saji T, Sakai S, Tanabe N, Watanabe H, Yamada H, Yoshioka K, Sasayama S.
  • Journal Title: Circ J. Volume: 80(6) Pages: 1478-1483
  • DOI: 10.1253/circj.CJ-15-1305
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Successful balloon pulmonary angioplasty with gadolinium contrast media for a patient with chronic thromboembolic pulmonary hypertension and iodine allergy. (2016)
  • Author(s): Nakamura T, Ogo T, Tsuji A, Fukui S, Fukuda T, Tahara N, Fukumoto Y, Yasuda S, Ogawa H, Nakanishi N.
  • Journal Title: Respir Med Case Rep. Volume: 17 Pages: 75-82
  • DOI: 10.1016/j.rmcr.2016.02.002. eCollection 2016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy and Safety of Inhaled Iloprost in Japanese Patients With Pulmonary Arterial Hypertension - Insights From the IBUKI and AIR Studies. (2016)
  • Author(s): Saji T, Myoishi M, Sugimura K, Tahara N, Takeda Y, Fukuda K, Olschewski H, Matsuda Y, Nikkho S, Satoh T.
  • Journal Title: Circ J. Volume: 80(4) Pages: 835-842
  • DOI: 10.1253/circj.CJ-16-0097
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] FDG-PET reveals coronary artery inflammation proceeding to cardiac allograft vasculopathy progression. (2016)
  • Author(s): Sasaki M, Tahara N, Abe T, Ueno T, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: 37(30) Pages: 2413
  • DOI: 10.1093/eurheartj/ehw082
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] FDG-PET/CT images during 5 years before acute aortic dissection. (2016)
  • Author(s): Tahara N, Hirakata S, Okabe K, Tahara A, Honda A, Igata S, Kaida H, Abe T, Akashi H, Tanaka H, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: 37(24) Pages: 1933
  • DOI: 10.1093/eurheartj/ehw075
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optical frequency-domain imaging and pulmonary angioscopy in chronic thromboembolic pulmonary hypertension. (2016)
  • Author(s): Chibana H, Tahara N, Itaya N, Sasaki M, Sasaki M, Nakayoshi T, Ohtsuka M, Yokoyama S, Sasaki K, Ueno T, Fukumoto Y.
  • Journal Title: Eur Heart J. Volume: 37(16) Pages: 1296-1304
  • DOI: 10.1093/eurheartj/ehv736
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Vascular inflammation evaluated by FDG-PET/CT in adult patients with a history of Kawasaki disease (2017)
  • Author(s): 田原宣広
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市、石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Clinical monitoring of inflammatory activity in atherosclerotic disease (2017)
  • Author(s): 田原宣広
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢市、石川県
  • Year and Date: 2017-03-17 – 2017-03-19
  • Invited
• [Presentation] Positron emission tomographyを用いた脳心血管病の評価 (2016)
  • Author(s): 田原宣広
  • Organizer: 脳心血管抗加齢研究会2016
  • Place of Presentation: 東京都
  • Year and Date: 2016-12-16 – 2016-12-17
  • Invited
• [Presentation] Right ventricular mechanical dyssynchrony in pulmonary hypertension is associated with right ventricular performance and pulmonary hemodynamics (2016)
  • Author(s): Igata S, Tahara N, Tahara A, Honda A, Nitta Y, Sugiyama Y, Munehisa B, Nakamura T, Kumanomido J, Kumagai E, Fukumoto Y
  • Organizer: The American Heart Association, Scientific Sessions (AHA 2016)
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12 – 2016-11-15
  • Int'l Joint Research
• [Presentation] Myocardial Glucose Metabolism Evaluated by Fasting 18F-fluorodeoxyglucose (2016)
  • Author(s): Nakamura T, Tahara N, Sugiyama Y, Bekki M, Tahara A, Honda A, Kaida H, Kumagai E, Igata S, Fukumoto Y
  • Organizer: The American Heart Association, Scientific Sessions (AHA 2016)
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12 – 2016-11-15
  • Int'l Joint Research
• [Presentation] Clinical monitoring of inflammatory activity in atherosclerotic disease (2016)
  • Author(s): 田原宣広
  • Organizer: 第56回日本核医学会学術総会
  • Place of Presentation: 名古屋市、愛知県
  • Year and Date: 2016-11-03 – 2016-11-05
  • Invited
• [Presentation] 肺血管拡張薬が右室におよぼす影響 (2016)
  • Author(s): 田原宣広
  • Organizer: 第1回肺高血圧学会
  • Place of Presentation: 東京都
  • Year and Date: 2016-10-01 – 2016-10-02
  • Invited
• [Presentation] Vascular inflammation is associated with periodontal inflammation evaluated by FDG-PET/CT (2016)
  • Author(s): Nakamura T, Tahara N, Kaida H, Bekki M, Sugiyama Y, Tahara A, Honda A, Igata S, Fukumoto Y
  • Organizer: The 5th International Congress on Lipid Metabolism & Atherosclerosis 2016
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-09 – 2016-09-10
  • Int'l Joint Research / Invited
• [Presentation] Diagnosis and Treatment of Cardiac Sarcoidosis guided by FDG-PET (2016)
  • Author(s): 田原宣広
  • Organizer: 第63 回日本不整脈心電学会学術大会
  • Place of Presentation: 札幌市、北海道
  • Year and Date: 2016-07-14 – 2016-07-17
  • Invited
• [Presentation] 心アミロイドーシスの診断と生命予後 (2016)
  • Author(s): 田原宣広
  • Organizer: 第2回心筋症研究会
  • Place of Presentation: 松本市、長野県
  • Year and Date: 2016-05-14 – 2016-05-14
  • Invited
• [Book] Diagnosis Treatment of Pulmonary Hypertension: From Bench to Bedside Treatment of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) (2016)
  • Author(s): Tahara N, Nakamura T, Chibana H , Kumagai E, Sugiyama Y, Bekki M, Honda A, Tahara A, Igata S, Fukumoto Y
  • Total Pages: 280 (93-99)
  • Publisher: Springer
• [Book] Annual Review 循環器 (2016)
  • Author(s): 元山貞子、皿井正義、松本有司、田原宣広
  • Total Pages: 280 (119-128)
  • Publisher: 中外医学社
• [Book] 右心不全を識り 評価して治療に活かす (2016)
  • Author(s): 中村知久、田原宣広、福本義弘
  • Total Pages: 169 (86-93)
  • Publisher: 文光堂