Immnunological disorder for coronary atherosclerosis in epicardial tissue

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461111
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Hiroshima University
• Principal Investigator: Yamamoto Hideya 広島大学, 医歯薬保健学研究院(医), 准教授 (70335678)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 冠動脈粥状硬化 / 免疫グロブリン（IｇG4) / 炎症 / 内臓脂肪

Outline of Final Research Achievements

We demonstrated that neovascularization and inflammatory cell infiltration are associated with non-calcified plaque detected by coronary CT angiography in coronary adiposity tissue, which are resected in patients undergoing open heart surgery. Our results suggested the hypothesis that coronary atherosclerosis is reflected from coronary advential inflammation and neovascularization.
Periaortitis which is a complication of IgG4 related disease (IgG4-RD) has elevated serum c-reactive (CRP) protein levels. It is well known that disorder of T- cell type 2 or regulatory T cell may cause the pathogenesis of IgG4-RD. Our findings suggested that IgG4-periaortitis may be associated with atherosclerotic plaque, and elevated CRP may be reflected by vascular inflammation.

Free Research Field

循環器病学