Exploratory research of atherosclerosis risk by HDL function evaluation and haptoglobin typing

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461116
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Yoshida Hiroshi 東京慈恵会医科大学, 医学部, 教授 (30333529)
• Research Collaborator: SHIMIZU Tomo ; MIYAZAKI Osamu ; HIRAISHI Chika ; SATO Ryo
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 動脈硬化 / HDL / コレステロール引き抜き能 / 安定同位体

Outline of Final Research Achievements

To establish cholesterol efflux capacity (CEC) method with stable isotope-labeled cholesterol, a fundamental method to progress this study project, was viewed as a critical issue to be addressed. The incidence of cardiovascular events is inversely correlated, to a greater extent, with cholesterol efflux capacity (CEC) than with HDL-cholesterol level. Here we established a CEC measurement technique using stable isotope-labeled cholesterol as an alternative to conventional radioisotope (RI)-labeled cholesterol.　Our established stable-isotope method will facilitate CEC measurement in clinical laboratories.

Free Research Field

動脈硬化