The development of molecular imaging on magnetic resonance for coronary atherosclerosis

2016 Fiscal Year Annual Research Report

• Project/Area Number: 26461119
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: 浅海 泰栄 国立研究開発法人国立循環器病研究センター, 病院, 医師 (20629315)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 核磁気共鳴画像法 / 冠動脈硬化症 / 病理学 / 画像診断 / 冠血行再建術

Outline of Annual Research Achievements

核磁気共鳴画像法(MRI)による冠動脈プラーク評価が　経皮的冠動脈インターベンション術(PCI)時の周術期心筋障害の発生を予測可能であることを報告した(2015年 JACC cardiovascular imaging誌)。またその病理組織像としてcomplex atheromaである可能性があることを報告した(2015年 Circulation Journal誌). また薬剤による冠動脈プラーク安定化作用をMRIを用いて世界で初めて可視化することに成功した(2015年 Journal of American college of Cardiology誌). 現在冠動脈MRI画像所見と病理像の実際を比較するため各種病理検体ライブラリーを作成して検証中である。また冠動脈プラーク容積を考慮した市販ソフトを用いた３次元冠動脈MRIプラーク評価法を考案し、その臨床的意義を2017年3月の日本循環器学会総会にて報告を行い現在論文投稿準備中である。また本研究期間内に侵襲的冠動脈造影を用いた予後予測法の検証も併せて行なった。冠動脈バイパス手術後の経皮的冠動脈インターベンション術(PCI)を施行した症例において検証を行なったところ、侵襲的冠動脈造影上、冠動脈硬化が非常に進展したと判定された症例において予後不良であることを示した（2016年 Circulation: cardiovascular interventions誌).
動物実験であるが大動物を用いた自然発生冠動脈硬化モデルを作成しその病理像を解析中である。
動脈硬化を特異的に認識するプローベ作成検討であるが、現時点での化学構造では蛍光標識体の動脈硬化に対する集積を認めないことから別途検証が必要な状況にある。

Research Products

• [Journal Article] Impact of Elevated End-Diastolic Pulmonary Regurgitation Gradient on Worse Clinical Outcomes in Hospitalized Patients With Heart Failure. (2017)
  • Author(s): Honda Y, Nagai T, Sugano Y, Honda S, Okada A, Asaumi Y, Aiba T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T
  • Journal Title: American Journal of Cardiology Volume: 119 Pages: 604-610
  • DOI: 10.1016/j.amjcard.2016.11.008
• [Journal Article] Validation of the Coronary Artery Bypass Graft SYNTAX Score (Synergy Between Percutaneous Coronary Intervention With Taxus) as a Prognostic Marker for Patients With Previous Coronary Artery Bypass Graft Surgery After Percutaneous Coronary Intervention. (2016)
  • Author(s): Miyagi T, Asaumi Y, Nishimura K, Nakashima T, Sakamoto H, Nakao K, Kanaya T, Nagai T, Shimabukuro Y, Miyamoto Y, Fujita T, Kusano K, Anzai T, Kobayashi J, Noguchi T, Ogawa H, Yasuda S.
  • Journal Title: Circulation: Cardiovascular Interventions Volume: 9 Pages: e003459
  • DOI: 10.1161/CIRCINTERVENTIONS.115.003459.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic impact of chronic total coronary occlusion on long-term outcomes in implantable cardioverter-defibrillator recipients with ischaemic heart disease. (2016)
  • Author(s): Nishikawa T, Fujino M, Nakajima I, Asaumi Y, Kataoka Y, Anzai T, Kusano K, Noguchi T, Goto Y, Nishimura K, Miyamoto Y, Kiso K, Yasuda S.
  • Journal Title: Europace Volume: N/A Pages: in press
  • DOI: 10.1093/europace/euw213
  • Peer Reviewed
• [Journal Article] Myocardial Immunocompetent Cells and Macrophage Phenotypes as Histopathological Surrogates for Diagnosis of Cardiac Sarcoidosis in Japanese. (2016)
  • Author(s): Honda Y, Nagai T, Ikeda Y, Sakakibara M, Asakawa N, Nagano N, Nakai M, Nishimura K, Sugano Y, Ohta-Ogo K, Asaumi Y, Aiba T, Kanzaki H, Kusano K, Noguchi T, Yasuda S, Tsutsui H, Ishibashi-Ueda H, Anzai T.
  • Journal Title: Journal of the American Heart Association Volume: 5 Pages: e004019
  • DOI: 10.1161/JAHA.116.004019
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of Geriatric Nutritional Risk Index for Assessing Nutritional Status and Its Prognostic Impact in Patients Aged Years With Acute Heart Failure. (2016)
  • Author(s): Honda Y, Nagai T, Iwakami N, Sugano Y, Honda S, Okada A, Asaumi Y, Aiba T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T.
  • Journal Title: American Journal of Cardiology Volume: 118 Pages: 550-555
  • DOI: 10.1016/j.amjcard.2016.05.045
  • Peer Reviewed
• [Journal Article] Prevalence, determinants, and prognostic significance of delirium in patients with acute heart failure. (2016)
  • Author(s): Honda S, Nagai T, Sugano Y, Okada A, Asaumi Y, Aiba T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T
  • Journal Title: International Journal of Cardiology Volume: 222 Pages: 521-527
  • DOI: 10.1016/j.ijcard.2016.07.236
  • Peer Reviewed
• [Journal Article] Time to Reperfusion in ST-Segment Elevation Myocardial Infarction Patients With vs. Without Pre-Hospital Mobile Telemedicine 12-Lead Electrocardiogram Transmission. (2016)
  • Author(s): Kawakami S, Tahara Y, Noguchi T, Yagi N, Kataoka Y, Asaumi Y, Nakanishi M, Goto Y, Yokoyama H, Nonogi H, Ogawa H, Yasuda S.
  • Journal Title: Circulation Journal Volume: 80 Pages: 1624-1633
  • DOI: 10.1253/circj.CJ-15-1322
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of endogenous erythropoietin in long-term outcome of patients with acute decompensated heart failure. (2016)
  • Author(s): Nagai T, Nishimura K, Honma T, Higashiyama A, Sugano Y, Nakai M, Honda S, Iwakami N, Okada A, Kawakami S, Kanaya T, Asaumi Y, Aiba T, Nishida Y, Kubota Y, Sugiyama D, Okamura T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T
  • Journal Title: European Journal of Heart Failure Volume: 18 Pages: 803-813
  • DOI: 10.1002/ejhf.537
  • Peer Reviewed / Open Access
• [Journal Article] Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture. (2016)
  • Author(s): Maruyama S, Nakamura K, Papanicolaou KN, Sano S, Shimizu I, Asaumi Y, van den Hoff MJ, Ouchi N, Recchia FA, Walsh K.
  • Journal Title: EMBO Molecular Medicine Volume: 8 Pages: 949-966
  • DOI: 10.15252/emmm.201506151
  • Peer Reviewed / Open Access
• [Presentation] Three-dimensional measurements of coronary high-intensity plaques on T1-weighted magnetic resonance as a predictor of cardiac events during percutaneous coronary intervention (2017)
  • Author(s): Hayato Hosoda, Yasuhide Asaumi, Teruo Noguchi, Yoshiaki Morita, Yu Kataoka, Tomoaki Kanaya, Kazuhiro Nakao, Fumiyuki Otsuka, Shoji Kawakami, Masashi Fujino, Takahiro Nakashima, Toshiyuki Nagai, Kensaku Nishihira, Michikazu Nakai, Kunihiro Nishimura, Hisao Ogawa, Satoshi Yasuda
  • Organizer: 第81回日本循環器学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] The Limited Efficacy of Rotational Atherectomy in Patients with Kawasaki Disease; A Long-term Follow up Study (2017)
  • Author(s): 浅海泰栄, 柳生剛, 津田悦子, 白石公、野口暉夫、 安田聡
  • Organizer: 第81回日本循環器学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Impact of Optimal Medical Therapy After Percutaneous Coronary Intervention as Secondary Revascularization in Patients with Prior Coronary Artery Bypass Grafting. (2017)
  • Author(s): Yuichi Nakamura, Yasuhide Asaumi, Tadayoshi Miyagi, Takahiro Nakashima, Shoji Kawakami, Masashi Fujino, Toshiyuki Nagai, Kazuhiro Nakao, Kensaku Nishihira, Fumiyuki Otsuka, Tomoaki Kanaya, Yu Kataoka, Teruo Noguchi, Yasuchika Takeishi, Satoshi Yasuda
  • Organizer: 第81回日本循環器学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Risk Stratification Using Biomarker for Fatal Arrhythmic Events Following Acute Myocardial Infarction Complicated with Left Ventricular Dysfunction in the Reperfusion Era (2016)
  • Author(s): Nao Konagai, Yasuhide Asaumi, Tatsuhiro Shibata, Noriaki Moriyama, Kunihiro Nishimura, Takahiro Nakashima, Shoji Kawakami, Masashi Fujino, Kazuhiro Nakao, Toshiyuki Nagai, Kensaku Nishihira, Reon Kumasaka, Tetsuo Arakawa, Tomoaki Kanaya, Yu Kataoka, Yoshio Tahara, Michio Nakanishi, Teruo Noguchi, Satoshi Yasuda
  • Organizer: American Heart Association Scientific Session 2016
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] 冠動脈造影に基づいた心筋虚血量推測から予後予測は可能か？ 冠動脈バイパス術後症例における経皮的冠動脈カテーテルインターベンション術の予後検証から (2016)
  • Author(s): 浅海泰栄、宮城唯良、西村邦宏、中島啓裕、 坂本裕樹、藤田知之、小林順二郎、野口暉夫、安田聡
  • Organizer: 第64回日本心臓病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-23 – 2016-09-25
• [Presentation] Trend of clinical outcome and predictor for in-hospital mortality in patients with unprotected left main coronary artery disease-culprit acute myocardial infarction; Institutional prospective registry study between 2000 and 2015. (2016)
  • Author(s): Tetsufumi Motokawa, Yasuhide Asaumi, Satoshi Honda, Shoji Kawakami, Toshiyuki Nagai, Tomoaki Kanaya Teruo Noguchi, Hisao Ogawa, and Satoshi Yasuda
  • Organizer: European Society of Cardiology Scientific Session 2016
  • Place of Presentation: Roma Italy
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] The importance of baseline coronary flow velocity in patients with normal coronary flow reserve but low fractional flow reserve to identify myocardial ischemia. (2016)
  • Author(s): Yasuyuki Honda, Yasuhide Asaumi, Shuji Hashimoto, Toshiyuki Nagai, Teruo Noguchi, Hisao Ogawa, And Satoshi Yasuda
  • Organizer: European Society of Cardiology Scientific Session 2016
  • Place of Presentation: Roma Italy
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] Prognostic impact of clinical presentation on admission and target vessel for percutaneous coronary intervention in patients with prior coronary artery bypass grafting (2016)
  • Author(s): Tadayoshi Miyagi, Yasuhide Asaumi, Teruo Noguchi, Hisao Ogawa and Satoshi Yasuda
  • Organizer: European Society of Cardiology Scientific Session 2016
  • Place of Presentation: Roma Italy
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Remarks] 冠動脈バイパス術後のカテーテル治療成果の評価
  • URL: http://www.ncvc.go.jp/pr/release/20160908_press.html