Molecular biological approach to the pathogenesis of coronary spastic angina: A study on the role of p122 protein

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461120
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Hirosaki University
• Principal Investigator: Okumura Ken 弘前大学, 医学研究科, 客員研究員 (20185549)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 循環器・高血圧 / 冠攣縮 / phospholipase C

Outline of Final Research Achievements

We recently generated transgenic mice with enhanced phospholipase C-delta 1 activity (PLC-TG) and reported enhanced coronary vasomotility such as that seen in patients with coronary spastic angina. In the present study, we showed the efficacy of calcium antagonist for coronary spasm and its mechanism using the PLC-TG mice. Alterations in activity of calcium channels were suggested to be implicated in the therapeutic effect of calcium antagonist. Furthermore, we first clarified roles of A-kinase anchoring proteins in the coronary spasm. The present study may help better understand mechanism of the coronary spasm and contribute to the development of novel treatment strategy for drug-resistant coronary spasm.

Free Research Field

循環器内科学、不整脈学