Impacts of Dysfunction in Cardiac Macrophages on Arrhythmia

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Fujiu Katsuhito 東京大学, 医学部附属病院, 特任准教授 (30422306)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 不整脈 / 心不全 / マクロファージ / 炎症

Outline of Final Research Achievements

We have studied the novel function of cardiac resident macrophage on cardiac physiological function. First we found the cardiac macrophage is required for its stress response against cardiac pressure overload. In addition, making cardiac rhythm is another cardiac basic role beyond cardiac contraction. Macrophage depleted mouse by clodronate liposome administration resulted in severe arrhythmia and death. These results indicated cardiac macrophages are involved in cardiac rhythm making.

Free Research Field

循環器内科学