2016 Fiscal Year Final Research Report
Mst1 promotes progression of dilated cardiomyopathy by modulating immune system
| Project/Area Number |
26461126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MAEJIMA YASUHIRO 東京医科歯科大学, 医学部附属病院, 講師 (40401393)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI JUNICHI 東京大学, 医学系研究科, 特任准教授 (90313858)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 制御性T細胞 / 自己免疫性心筋炎 / リン酸化 |
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| Outline of Final Research Achievements |
We have previously shown that Mst1 phosphorylates FoxO1, a forehead transcription factor, thereby modulating cell survival of cardiomyocytes through induction of nuclear translocation of FoxO1. In this study, based on this finding, we explored that the role of Mst1 on Foxp3, another forehead transcription factor which regulates the function of regulatory T cell (Treg), and found that Mst1 modulates the progression of post-myocarditis dilated cardiomyopathy through phosphorylating Foxp3 through modulating Treg-mediated immune system.
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| Free Research Field |
循環器内科学
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