2016 Fiscal Year Final Research Report
The Role of Hemodynamic Stress in the Development/Maintenance of Occlusive Vascular Lesions in Severe Pulmonary Hypertension
| Project/Area Number |
26461146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
Abe Kohtaro 九州大学, 大学病院, 助教 (20588107)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肺高血圧症 / 閉塞性病変 / 炎症 |
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| Outline of Final Research Achievements |
An important pathogenic mechanism in the development of idiopathic pulmonary arterial hypertension is hypothesized to be a cancer-like cellular proliferation independent of hemodynamics. However, because the vascular lesions are inseparably coupled with hemodynamic stress, the fate of the lesions is unknown when hemodynamic stress is eliminated.
Our results indicate that hemodynamic stress is prerequisite to the development and progression of occlusive neointimal lesions in this rat model of severe pulmonary hypertension. We conclude that perivascular inflammation and occlusive neointimal arteriopathy are driven by hemodynamic stress.
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| Free Research Field |
肺高血圧症
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