2016 Fiscal Year Final Research Report
Establishment of a novel therapeutic strategy for atherosclerosis utilizing a focal adhesion adaptor molecule
| Project/Area Number |
26461149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | HIc-5 / 細胞接着斑 / 動脈硬化性疾患 |
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| Outline of Final Research Achievements |
Hydrogen peroxide-inducible clone-5 (Hic-5) is a focal adhesion adaptor protein, which is involved in vascular disorders such as atherosclerosis and aneurysms. To evaluate the therapeutic potential of Hic-5 in vascular disorders, Hic-5 siRNA was intravenously injected through the tail vein of the HCD-fed or AngII treated apoE deficient mice. Hic-5 knockdown significantly suppressed the formation of atherosclerotic and aneurysmal lesions. Moreover, we report the structure-based design of new potent peptides with Hic-5 inhibitory efficiency. The peptides are developed by rational design, based on structural and physicochemical properties. In vitro analysis shows that some of the peptides possess a significant inhibitory effect against Hic-5.
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| Free Research Field |
細胞生物学
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