Neutrophil Extracelluar Traps in Severe influenza-elated pneumonia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461158
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku Medical and Pharmaceutical University (2015-2016); Osaka University (2014)
• Principal Investigator: SEKI Masafumi 東北医科薬科大学, 医学部, 教授 (80432970)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: インフルエンザ / 肺炎 / サイトカインストーム / 好中球 / 敗血症 / ネッツ / ワクチン / 耐性菌

Outline of Final Research Achievements

The aim of this study is that examination whether excessive immunological reaction, including NETs (Neutrophil Extracellular Traps) make the damage to host and patients although these regularly could control the infectious pathogens.
We reported these possible cases including severe influenza-related pneumonia, and analyzed mice models of sepsis and influenza infection. In addition, we investigated the diagnosis method including biomarkers (eg. procalcitonin) in clinical fields.

Free Research Field

呼吸器感染症