2016 Fiscal Year Final Research Report
Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant protein
| Project/Area Number |
26461164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA YOSHIHIRO 札幌医科大学, 医学部, 助教 (90643180)
SAITO ATSUSHI 札幌医科大学, 医学部, 助教 (00768939)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 急性肺傷害 / ブレオマイシン / 肺コレクチン / 肺サーファクタントタンパク質A / トル様受容体 / アレルギー性気道炎症 |
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| Outline of Final Research Achievements |
This study was performed to clarify the importance of pulmonary surfactant protein (SP-A) as an inhibitor of lung injury / fibrosis and allergic airway inflammation and its mechanism, and to show the results that will be a bridge to the therapeutic strategy. In SP-A knockout mice, intrapulmonary inflammation and fibrosis were significantly enhanced under bleomycin stimulation compared with wild type mice. When SP-A was further administered from the respiratory tract, the inflammation was suppressed. Furthermore, in vitro experiments revealed that the inhibitory effect of SP-A against inflammation was based on the inhibition of binding of bleomycin and soluble Toll-like receptor (sTLR2). In addition, the effect of suppressing allergic reaction in respiratory tracts was also confirmed.
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| Free Research Field |
医歯薬学
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