Identification of novel biomarkers for early diagnosis and monitoring of cardio-renal syndrome in chronic kidney disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461222
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: Suzuki Yasuhiro 名古屋大学, 医学系研究科, 寄附講座助教 (20584676)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: CKD / 心腎連関 / バイオマーカー

Outline of Final Research Achievements

We searched new biomarkers of cardio-renal syndrome in a mouse model with CKD. Some possible candidate substances reflecting CKD-related pathogenic changes in heart such as fibrosis were identified by metabolomics. The candidate substances were confirmed other animal models and in vitro experiments with a rat fibroblast cell line. When we also investigated serum candidate substances and echocardiography examinations in patients on peritoneal dialysis at our hospital, a significant correlation between the candidate substances and cardiac hypertrophy indicators were observed (P = 0.001, R2 = 0.25). It was suggested that some of our identified substances might play roles as new biomarkers to predict progress of cardiac fibrosis in patients with CKD.

Free Research Field

腎臓内科学