2017 Fiscal Year Final Research Report
The evaluation of role of prostasin in the proximal tubule with Pax8-rtTA/LC-1 system.
| Project/Area Number |
26461234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
Kakizoe Yutaka 熊本大学, 大学院生命科学研究部(医), 助教 (70583037)
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| Co-Investigator(Kenkyū-buntansha) |
北村 健一郎 山梨大学, 大学院総合研究部, 教授 (10304990)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | プロスタシン / HAI-1 / セリンプロテアーゼ / 慢性腎臓病 / アルドステロン |
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| Outline of Final Research Achievements |
In this study, we evaluated the role of a serine protease prostasin in the pathogenesis of chronic kidney injury, particularly renal interstitial fibrosis, using renal tubule specific prostasin and its endogenous inhibitor, HAI-1, knock out mice. No amelioration or exaggeration of renal injury was observed in aldosterone/salt model and unilateral ureter obstruction model. Furthermore, the deletion of HAI-1 had no effect on the renal tubule necrosis caused by cisplatin. Our study suggests that renal tubular prostasin and HAI-1 are not associated with renal injury in those disease model.
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| Free Research Field |
腎臓病学
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