2016 Fiscal Year Final Research Report
Effects of renal sympathetic nervous and L-FABP on oxidative stress response in the brain
Project/Area Number |
26461261
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Juntendo University |
Principal Investigator |
|
Research Collaborator |
TAKAHASHI Keiko 順天堂大学, 腎臓内科, 非常勤助手
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | 酸化ストレス / 中大脳動脈虚血再灌流 / 腎交感神経 / L-FABP |
Outline of Final Research Achievements |
To investigate the roles of sympathetic nerve system (SNS) and oxidative stress in cerebro-cardio-renal syndrome (CRS), we developed cerebral ischemia/ reperfusion (IR) model and evaluated the impacts of renal sympathetic nerve denervation (RD) or an endogenous inhibitor for oxidative stress, L-FABP overexpression on this model. Unexpectedly, pretreatment of RD rather tended to enhance the mortality and infarction area after IR, suggesting that SNS could play an important role in maintaining the blood flow as well as the homeostasis in the acute phase of IR. We are now investigating the detail involvements of SNS activation in acute/ chronic phase of IR by modulating the timing of RD in the IR model.
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Free Research Field |
酸化ストレス
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