2016 Fiscal Year Final Research Report
Analysis of mutational mechanism of JC virus in patients with progressive multifocal leukoencephalopathy during mefloquine administration
| Project/Area Number |
26461286
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Nakamichi Kazuo 国立感染症研究所, ウイルス第一部, 主任研究官 (50348190)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOKAWA Toshio 和歌山県立医科大学, 臨床研究センター, 准教授 (00402090)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ウイルス / 脳 / 神経 / 脳神経疾患 |
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| Outline of Final Research Achievements |
Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease caused by JC polyomavirus (JCV) infection. JCV isolates from PML patients have variable mutations in the viral genome. In this study, we have comprehensively analyzed the mutational patterns of JCV isolates obtained from the cerebrospinal fluid of PML patients. We have also examined the relationship between JCV mutation and disease progression.
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| Free Research Field |
神経感染症学
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