2016 Fiscal Year Final Research Report
Objective evaluation methods of neuropathic pain by axonal excitability testing and brain imaging
| Project/Area Number |
26461305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 神経障害性疼痛 / 軸索興奮性測定 / 脳機能画像 |
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| Outline of Final Research Achievements |
We aimed to develop methods to evaluate changes in the peripheral and central nervous systems by using axonal excitability testing, pain-related brrain potentials, and functional brain imagings. Compared with normal controls, patients with neuropathic pain showed significantly increased sodium currents in the peripheral sensory axons, exaggerated pain-related brain potentials, and increased cerebral blood flow in the anterior cingulate gyrus. These findings suggest that peripheral generation of extopic impulses could lead to central sensitization, particularly in the limbic system, and thereby chronic persistent pain.
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| Free Research Field |
医歯薬学
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