2016 Fiscal Year Final Research Report
The elucidation of the mechanisms of subthalamic nucleus deep brain stimulation on higher micturition centre
| Project/Area Number |
26461306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | パーキンソン病 / 視床下核脳深部刺激療法 / 高位排尿中枢 |
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| Outline of Final Research Achievements |
Although it is well known that the subthalamic nucleus deep brain stimulation (STN-DBS) dramatically improve motor complication, the effect of STN-DBS on lower urinary tract dysfunction remains to be elucidated. We examined the effect of STN-DBS on higher micturition centrre such as prefrontal cortex by recording extracellular potential and neurotransmitter using normal and Parkinson's disease model rat.
The extracellular potential of higer micturition centre was changed by STN-DBS. The levels of neurotransmitter such as catecholamine were also changed by STN-DBS. The effect of STN-DBS on extracellular potential and neurotransmitter in higher micturition centre differed significantly between normal and Parkinson's disease model rat. These findings suggested the STN-DBS might regulate the micturition reflex by changing the activity of higher micturition centre differently between normal and Parkinson's disease model rat.
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| Free Research Field |
神経内科学
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