2016 Fiscal Year Final Research Report
A study of the correlation between myoclonic seizure and molecular mechanism induced by focal cortical dysplasia.
| Project/Area Number |
26461312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | てんかん / 実験てんかん / ミオクロニー発作 / 皮質異形成 |
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| Outline of Final Research Achievements |
On embryonic day (E) 18, a frozen prove was placed on the frontal scalp of a Sprague-Dawley rat embryo through the uterus wall to produce multiple (one or two) freeze lesions on each hemisphere. FCD rat models were divided to group A (one lesion on the left), group B (two lesions on the left) and group C (one lesion on the each frontal areas). All rats were performed EEG monitoring with electrical stimulation onto the scalp electrodes from postnatalday (P) 1 to P7. The number of animals of group C showing myoclonic seizure was significantly more than the other groups on P1, however there was no significance between all groups through the stimulations. Immunoreactivities for N-methyl-D-aspertate receptors and glutamate transporters in FCD lesions were significantly enhanced compared to controls.
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| Free Research Field |
てんかん
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