2016 Fiscal Year Final Research Report
Calcium-signaling abnormality of polyglutamine diseases
| Project/Area Number |
26461315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ポリグルタミン病 / カルシウムシグナリング |
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| Outline of Final Research Achievements |
We examined association of polyglutamine disease and the calcium-signaling abnormality. Polyglutamine diseases are chronic, progressive neurodegenerative diseases caused by expansion of a glutamine tract in widely expressed genes and a heterogeneous group of dominantly inherited neurodegenerative disorders affecting the cerebellum and its associated pathways. These cause proteins are associated with cell death by calcium-signaling abnormality. We determined the possibility that a CACNA1A calcium channel in the polyglutamine disease was associated with abnormal cause protein formation of polyglutamine disease and identified a calcium channel subtype binding to cause protein. We confirmed the distribution of the calcium channel subtype expressions showed possibility reflecting a lesion of each polyglutamine disease and showed resistibility and vulnerability for the neurodegeneration.
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| Free Research Field |
神経内科
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