Study of physiological back ground of motor axonal ion channel dysfunction in amyotrophic lateral sclerosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26461319
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: Kanai Kazuaki 順天堂大学, 医学部, 准教授 (10375751)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 筋萎縮性側索硬化症 / チャネロパチー / 神経軸索興奮特性 / ナトリウムチャンネル / 神経変性

Outline of Final Research Achievements

We performed the nerve excitability measurements in patients with amyotrophic lateral sclerosis. We confirmed that changes in some indices of nerve excitability measurements such as strength-duration time constant (SDTC) or early component of depolarizing threshold electrotonus (TEd10-30) were strong indicators of prognosis of patients with amyotrophic lateral sclerosis. We found changes in SDTC and TEd10-30 were associated with those in the already known prognostic factors. We performed the measurements of miRNA in patients with amyotrophic lateral sclerosis. We compared the results of nerve excitability measurements and of miRNA in patients with amyotrophic lateral sclerosis.

Free Research Field

臨床神経生理学