2016 Fiscal Year Final Research Report
The role of vaspin in metabolic syndrome associated renal disease
| Project/Area Number |
26461361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
WADA Jun 岡山大学, 大学院医歯薬学総合研究科・腎・免疫・内分泌代謝内科学, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | メタボリックシンドローム / 慢性腎臓病 / アディポカイン |
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| Outline of Final Research Achievements |
We previously identified an adipokine, vaspin. In this study, we checked the beneficial role of vaspin in renal injury of metabolic syndrome. Vaspin transgenic(Tg) and vaspin-/- mice were fed with high fat high sucrose (HFHS) diet. At 30 weeks of age, prominent vacuolation in the kidney tissues of vaspin-/- mice under HFHS diet are observed, and it is meliorated in Tg mice. These vacuoles are toluidine blue positive and EM demonstrates lysosomal enlargement. TUNEL-positive apoptotic tubular cells increase in vaspin-/- mice fed with HFHS compared with Tg and wild type mice. Next, we investigated the streptozotocin(STZ) induced-diabetes model. In Tg mice, the dilatation and thinning of tubules induced by diabetes are ameliorated. TUNEL-positive apoptotic cells are increased in STZ induced diabetic vaspin-/- mice, while in Tg mice apoptosis was inhibited. It is suspected that vaspin ameliorate tubulointerstitial injury in diabetic and metabolic syndrome associated renal disease.
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| Free Research Field |
代謝・糖尿病・腎臓
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