2016 Fiscal Year Final Research Report
Contribution of KATP channel in PVN oxytocin neurons for food intake regulation.
| Project/Area Number |
26461366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Maejima Yuko 福島県立医科大学, 医学部 医療エレクトロニクス研究講座 薬理学講座, 准教授 (40438669)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | オキシトシン / KATPチャネル |
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| Outline of Final Research Achievements |
Increase of obesity population is becoming a social problem. In order to solve this problem, elucidation of food intake regulation mechanism in brain is essential. In this study we have focused on KATP channel which is known to be regulated by glucose and influence the neuron activity. We found that KATP channel is indirectly regulating the activity of oxytocin neuron in paraventricular nucleus (PVN) in hypothalamus. Because PVN oxytocin neurons are important for food intake regulation, KATP channel may be a future target for the treatment of obesity.
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| Free Research Field |
電気生理学
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