2016 Fiscal Year Final Research Report
The new function of cave-in-1 in the ABCA1-mediated HDL biogenesis
| Project/Area Number |
26461370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Chubu University |
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Principal Investigator |
LU Rui 中部大学, 応用生物学部, 講師 (80381862)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ABCA1 / caveolin-1 / HDL |
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| Outline of Final Research Achievements |
Expression of ATP binding cassette transporter (ABC) A1, a key membrane protein for bio- genesis of high-density lipoprotein (HDL), is regulated not only by its gene transcription but also by its intracellular degradation to modulate plasma HDL concentration. We here undertook investigation of the role of caveolin-1 in the ABCA1- mediated HDL biogenesis in order to understand how cell cholesterol homeostasis is regulated by caveolin-1 function. In this study, we conclude that caveolin-1 enhances internalization and degradation of ABCA1 by its association with ABCA1. Interference of this interaction by probucol oxidative products suppresses ABCA1 degradation and increase HDL biogenesis.
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| Free Research Field |
分子生物学
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