Cytokines secreted from the liver affect bone mass.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461377
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kanazawa University
• Principal Investigator: Ishii Kiyoaki 金沢大学, 医学系, 特任准教授 (80419150)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨粗鬆症 / 糖尿病 / 老化 / 内分泌

Outline of Final Research Achievements

We measured the bone morphology in Lect 2 knockout mice and found that the bone mass decreased as compared with the wild type mouse. Examination of bone metabolism markers in serum showed an increase in osteoclast activation marker TRAP 5b in Lect 2 KO mice. Even at the cellular level, osteoclasts were found to inhibit the differentiation of macrophages into mature osteoclasts by addition of Lect 2. In osteoblasts, there was no significant effect on the differentiation stage. However, in the postmenopausal osteoporosis model from which the ovaries were removed, there was no difference in the extent of bone loss in wild type and Lect 2 KO mice.

Free Research Field

代謝学