Elucidation of organelle network mechanism controlled by mitochondrial dynamics and its application.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461383
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kyushu University
• Principal Investigator: Nomura Masatoshi 九州大学, 大学病院, 講師 (30315080)
• Co-Investigator(Renkei-kenkyūsha): ISHIHARA Naotada 久留米大学, 分子生命科学, 教授 (10325516) ; YAMADA Yuma 北海道大学, 薬学研究院, 助教 (60451431)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ミトコンドリア / 糖尿病 / 小胞体ストレス / DRP1

Outline of Final Research Achievements

Mitochondria are highly dynamic organelles that frequently fuse and divide in response to cellular energy demands. In an excessive energy state such as a high fat diet, the organelle network between Mt and ER is impaired, followed by the induction of ER stress. As a result, FGF21 is secreted from the liver by activation of PERK-eIF2a-ATF4 pathway, and energy expenditure is accelerated in the peripheral organs such as skeletal muscle and adipose tissue. In other words, mitochondrial dynamics-ER stress-FGF21 axis function as a biological defense system for energy excess. Therefore, mitochondrial dynamics is a therapeutic target for the obese diabetes.

Free Research Field

内分泌代謝学