2016 Fiscal Year Final Research Report
A novel cytoprotective agent with thrombomodulin mutant
| Project/Area Number |
26461406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Fukushima Medical University (2016)
Kochi University (2014-2015) |
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Principal Investigator |
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| Research Collaborator |
NISHIOKA Chie 高知大学, 医学部, 研究員
YANG Jing 高知大学, 医学部, 外国人特別研究員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | thrombomodulin / transplantation |
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| Outline of Final Research Achievements |
We previously reported that the 4th and 5th epidermal growth factor like domain of thrombomodulin (TME45) possesses cytoprotective as well as pro-angiogenic activities. The current study has found that these activities were preserved in the TME5. Further studies employed immunoprecipitation followed by proteomic analysis to identify the cell surface protein which interacts with TME5. We found that TME5 binds to chemokine receptor GPR15, leading to activation of intracellular pro-survival signaling in vascular endothelial cells.
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| Free Research Field |
血栓止血学
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