2016 Fiscal Year Final Research Report
Functional disruption of leukemia microenvironment by leukemia p53
| Project/Area Number |
26461425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
|
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| Research Institution | Saga University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 白血病 / p53 / 微小環境 / 幹細胞 / MDM2 |
|---|
| Outline of Final Research Achievements |
We investigated an interaction between leukemia cells and stromal cells. Using newly developed leukemia microenvironment models, we found that (1) p53 activation by irradiation, treatment with certain classes of chemotherapeutic agents or MDM2 inhibition can decrease expression levels of PD-L1 in leukemia cells and reduce secretion of SDF-1 (CXCL12) from stromal cells, and (2) BMI-1 inhibition actively disrupt the leukemia-stroma interaction through inducing cell death in leukemia cells and inhibiting stromal functions. Novel strategies targeting leukemia-stroma interaction may improve therapeutic outcome of leukemias.
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| Free Research Field |
造血器腫瘍分子標的治療学
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