2016 Fiscal Year Final Research Report
Analysis of the functions of MUSE in the lymphoma microenvironment.
| Project/Area Number |
26461435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
DEZAWA Mari 東北大学, 細胞組織学講座, 教授 (50272323)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 体性幹細胞 / がん微小環境 / 血管新生 |
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| Outline of Final Research Achievements |
The tumor microenvironment favors the tumor growth and enhanced the chemo-sensitivity of tumors. However, little is known about the mechanism what a kind cell forms the tumor microenvironment and where they come from so far. We found that multilineage-differentiating stress-enduring (Muse) cells reside in lymphoma tissues. Elevated expression of FGF2 has been reported in hematological malignancies, and is prognostically significant for malignant lymphoma. FGF2 significantly modulated expression of genes related to angiogenesis such as VEGF-A, Ang-1 in osteoblasts, a component of the tumor microenvironment, suggesting that FGF2 promotes angiogenesis. Migration assays showed that supernatants of lymphoma cells enhanced migration of MUSE cells. Thus, we concluded that MUSE cells migrate towards the lymphoma tumor via newly formed vasucularities by FGF2.
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| Free Research Field |
血液内科学
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