Role of tenascin-C in development of fibrosis in chronic GVHD tissue and establishment of its targetted therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26461441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Mie University
• Principal Investigator: Tawara Isao 三重大学, 医学系研究科, 助教 (80378380)
• Research Collaborator: Kitano Shigehisa 国立がん研究センター, 中央病院, 医員 (60402682) ; Ito Ayumu 国立がん研究センター, 中央病院, 医員
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: GVHD / テネイシン-C

Outline of Final Research Achievements

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for refractory hematological malignancies. Complication occured after allo-HSCT such as graft-vs-host disease (GVHD) is an obstacle for successful allo-HSCT. Pathophysioligy of chronic GVHD (cGVHD) that features tissue fibrosis is still unclear and standard therpy for cGVHD has not been established yet.
Tenascin-C (TN-C)is involved in tissue fibrosis and its role in cGVHD pathophysiolgy is unknown. In this study, we investigated the role of TN-C in cGVHD using mouse model and clinical samples. Mouse models demonstrated that TN-C was produced by recipient-origin cells and there was a tendency that GVHD was exacerbated in TN-C-deficient mice. Analysis of relation between TN-C level in patient's plasma and cGVHD onset is underway.

Free Research Field

血液内科学