2016 Fiscal Year Final Research Report
Multiple developmental origins of adult blood cell lineages and its relevance to functions
| Project/Area Number |
26461442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
|
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| Research Collaborator |
ITO Chie
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 造血発生 / 細胞分化 / 造血幹細胞 / 発生 / 卵黄嚢 / マクロファージ / NK細胞 / B-1 B細胞 |
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| Outline of Final Research Achievements |
In recent years, it has been shown that some mature blood cells originated from embryonic stages persist in adult bodies independently from hematopoietic stem cells (HSC). In this study, we searched the origins of these HSC-independent cell lineages and examined the functional differences between embryo-derived cells and HSC-derived cells. Our study indicated the origin of some macrophages and NK cells in the yolk sac. In addition, we observed a functional differences between yolk sac-derived and adult HSC-derived NK cell lineages.
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| Free Research Field |
血液学 免疫学 幹細胞生物学 発生学
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