2016 Fiscal Year Final Research Report
The role of STAP-2 in hematological diseases
| Project/Area Number |
26461444
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA Tetsuo 大阪大学, 医学系研究科, 助教 (00403064)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | STAP蛋白 / アダプター蛋白 |
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| Outline of Final Research Achievements |
Previously, we have reported that Signal transducing adaptor protein (STAP) binds latent membrane protein-1 in Epstein-Barr virus (EBV), and Bcr-Abl fusion protein, which causes chronic myeloid leukemia (CML). In this study we studied the role of STAP family in various hematological diseases. We found that STAP-1 is down-regulated in EBV-induced post transplantation lymphoproliferative disorder compared with EBV-negative de novo DLBCL. Regarding the effect on CML, STAP-1 deficiency improved the survival of CML model mouse. Further study would clarify the precise molecular mechanisms.
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| Free Research Field |
血液内科
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