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2016 Fiscal Year Final Research Report

Development of novel immunotherapy targeting leukemic stem cells.

Research Project

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Project/Area Number 26461453
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionKeio University

Principal Investigator

Matsushita Maiko  慶應義塾大学, 薬学部(芝共立), 准教授 (10327520)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords白血病幹細胞 / がん抗原 / CTL / 脱メチル化剤
Outline of Final Research Achievements

Novel cancer antigen, CXorf48, was highly expressed in patients-derived leukemic stem cells. Cytotoxic T cells induced with HLA-A24-restricted epitope could recognize these leukemic stem cells from leukemic patients. We also found the correlation between existence of anti-CXorf48 CTL in peripheral blood of leukemic patients and their clinical courses.
Moreover, demethylating agent up-regulated expression of CXorf48 gene in leukemic cells, but not in normal blood cells, suggesting that combination of demethylating agent with immunotherapy might be effective. Therefore, immnotherapy targeting CXorf48 would be a promising treatment for leukemia by eradicating leukemic stem cells.

Free Research Field

腫瘍免疫学 血液内科学

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Published: 2018-03-22  

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