2016 Fiscal Year Final Research Report
The role of Foxp3+ CD3- innate cells in allergic airway inflammation
| Project/Area Number |
26461486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アレルギー性気道炎症 / 自然リンパ球 |
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| Outline of Final Research Achievements |
In this study, we examined the role of Foxp3+ CD3- innate cells and the new mechanism to regulate allergic inflammation.
a) B220, MHC classII, and CCR6 were expressed on Foxp3+ CD3- cells from spleen of hCD2-Foxp3 reporter mice. b) IAIE+ Foxp3+ CD3- cells in the lungs of hCD2-Foxp3 reporter mice were increased after intranasally papain administration. Those results suggest that Foxp3+ CD3- cells were induced in the lungs to regulate allergic airway inflammation without anti-inflammatory cytokine secretion.
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| Free Research Field |
アレルギー学
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