2016 Fiscal Year Final Research Report
Study for a development of a treatment of ASD with a clomosome duplicated ASD model mouse.
| Project/Area Number |
26461554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Takumi Toru 理化学研究所, 脳科学総合研究センター, 教授 (00222092)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 自閉症 / 社会性 / セロトニン / 背側縫線核 |
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| Outline of Final Research Achievements |
We investigated a way of treatment for ASD by using a chromosome duplicated ASD model mouse (15q-dup).
Because the serotonin content in the brain of 15q-dup mouse was decreased from neonatal period, we tried a treatment with a selective serotonin re-uptake inhibitor, fluoxetine, during 3 weeks after birth. The lower sociability and brain 5-HT level were ameliorated in adult 15q-dup mice, but their persistent behavior and repetitive behavior were not. Electrophysiological experiments revealed that 5-HT neurons had more hyperpolarized resting membrane potentials and smaller excitatory glutamatergic inputs in the dosal raphe nucleus in 15q-dup mice compared with the wildtype. In association with the serotonin restoration, neonatal FLX treatment also ameliorated these electrophysiological of 15q-dup mice. （Science Advances, in press）
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| Free Research Field |
神経薬理学
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